Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0QA 4-[methyl(nitroso)amino]-1-(pyridin-3-yl)butan-1-one
GOL Glycerol
HEM Protoporphyrin ix containing Fe
Code : 4EJH
Header : OXIDOREDUCTASE
Title : Human Cytochrome P450 2A13 in complex with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
Release Data : 2012-06-06
Compound :
mol_id molecule chains synonym
1 Cytochrome P450 2A13 A,B,C,D,E,F,G,H CYPIIA13
ec: 1.14.14.1
fragment: unp residues 31-494
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CYP2A13
expression_system_strain: TOPP3
expression_system_vector_type: plasmid
expression_system_plasmid: pKK2A13dH
Authors : DeVore, N.M., Scott, E.E.
Keywords : CYP2A13, cytochrome P450 2A13, P450 2A13, heme protein, monooxygenase, drug metabolism, xenobiotic metabolism, endoplasmic reticulum, membrane, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.35 Å )
Citation :

Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes.

DeVore, N.M.,Scott, E.E.
(2012)  J.Biol.Chem.  287 : 26576 - 26585

PubMed: 22700965
DOI: 10.1074/jbc.M112.372813

Chain : A, B, C, D, E, F, G, H
UniProt : Q16696 (CP2AD_HUMAN)
Reaction : RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.