Het-PDB Navi2 (PDB: 4EGH)

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Ligands
Code	Name		Style	Show	Link
MG	Magnesium ion				PoSSuM
0OY	(4-hydroxyphenyl)(morpholin-4-yl)methanone				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4EGH

Code :

4EGH PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Hsp90-alpha ATPase domain in complex with (4-Hydroxyphenyl)morpholin-4-yl methanone

Release Data :

2012-05-23

Compound :

mol_id	molecule	chains	synonym
1	Heat shock protein HSP 90-alpha	A	Heat shock 86 kDa, HSP 86, HSP86, Renal carcinoma antigen NY-REN-38
	fragment: N-terminal domain, residues 9-236 other_details: N-terminal domain

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: HSP90AA1, HSP90A, HSPC1, HSPCA expression_system_strain: BL21-DE3 expression_system_plasmid: pET-28a

Authors :

Chen, W.J., Wood, S.P.

Keywords :

Bergerat Fold, Hydrolase, ATP binding, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.60 Å )

Citation :

Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors.

Austin, C.,Pettit, S.N.,Magnolo, S.K. et al.
(2012) J Biomol Screen 17 : 868 - 876

Chain :

UniProt :

P07900 (HS90A_HUMAN)

PDB ID: 4EGH