Brand  (β version)

PDB ID: 4EG2

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
URI Uridine PoSSuM
ACT Acetate ion PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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MSE Selenomethionine
Glycosylation
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Structure summary

Code : 4EG2   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : 2.2 Angstrom Crystal Structure of Cytidine deaminase from Vibrio cholerae in Complex with Zinc and Uridine
Release Data : 2012-05-02
Compound :
mol_id molecule chains synonym
1 Cytidine deaminase A,B,C,D,E,F,G,H Cytidine aminohydrolase, CDA
ec: 3.5.4.5
Source :
mol_id organism_scientific expression_system
1 Vibrio cholerae  (taxid:666) Escherichia coli  (taxid:866768)
gene: cdd, VC_1231
expression_system_strain: BL21-Gold(DE3)pLysS AG
expression_system_vector_type: plasmid
expression_system_plasmid: pMCSG7
Authors : Minasov, G., Wawrzak, Z., Skarina, T., Wang, Y., Grimshaw, S., Papazisi, L., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Keywords : Cytidine deaminase, UMP synthesis, ZN binding, Hydrolase, Structural Genomics, Center for Structural Genomics of Infectious Diseases, CSGID
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

2.2 Angstrom Crystal Structure of Cytidine deaminase from Vibrio cholerae in Complex with Zinc and Uridine.

Minasov, G.,Wawrzak, Z.,Skarina, T.  et al.
TO BE PUBLISHED 

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : Q9KSM5 (CDD_VIBCH)
Reaction: EC: Evidence:
Physiological Direction:
cytidine + H(+) + H2O = NH4(+) + uridine 3.5.4.5 HAMAP-Rule:MF_01558
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2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+) 3.5.4.5 HAMAP-Rule:MF_01558
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