Brand  (β version)

PDB ID: 4EF8

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
0FI N-phenylthioformamide PoSSuM
FMN Flavin mononucleotide PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4EF8   PDBj   RCSB PDB   PDBe
Header : Oxidoreductase/Oxidoreductase inhibitor
Title : Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate
Release Data : 2012-12-12
Compound :
mol_id molecule chains
1 Dihydroorotate dehydrogenase A,B
ec: 1.3.3.1
Source :
mol_id organism_scientific expression_system
1 Leishmania major  (taxid:5664) Escherichia coli  (taxid:469008)
strain: Friedlin
gene: DHODH, lmjf16.0530, LMJF_16_0530
expression_system_strain: Bl21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET28a
Authors : Pinheiro, M.P., Emery, F.S., Nonato, M.C.
Keywords : Leishmania major, dihydroorotate dehydrogenase, Phenyl isothiocyanate, pyrd, Oxidoreductase, Oxidoreductase-Oxidoreductase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.56 Å )
Citation :

Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase.

Pinheiro, M.P.,Emery, F.S.,Nonato, M.C.
(2013)  Curr.Pharm.Des.  19 : 2615 - 2627

PubMed: 23116399

Reaction

Chain : A, B
UniProt : Q4QEW7 (Q4QEW7_LEIMA)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + fumarate = orotate + succinate 1.3.98.1 ARBA:ARBA00001694, RuleBase:RU364042
-