Brand  (β version)

PDB ID: 4EC4

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
0O6 (3s,6s,7s,9as,3'S,6'S,7'S,9a'S)-N,N'-(benzene-1,4-diylbis{butane-4,1-diyl-1h-1,2,3-triazole-1,4-diyl[(S)-phenylmethanediyl]})bis[7-(hydroxymethyl)-6-{[(2s)-2-(methylamino)butanoyl]amino}-5-oxooctahydro-1h-pyrrolo[1,2-a]azepine-3-carboxamide] PoSSuM
P33 3,6,9,12,15,18-hexaoxaicosane-1,20-diol PoSSuM
Non-standard Residues
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Structure summary

Code : 4EC4   PDBj   RCSB PDB   PDBe
Header : APOPTOSIS INHIBITOR
Title : XIAP-BIR3 in complex with a potent divalent Smac mimetic
Release Data : 2012-12-05
Compound :
mol_id molecule chains synonym
1 Baculoviral IAP repeat-containing protein 4 A,B,C,D,E,J,F,G,K,L E3 ubiquitin-protein ligase XIAP, IAP-like protein, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP-3, hIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP
ec: 6.3.2.-
fragment: BIR3 domain (UNP residues 241-356)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: XIAP, API3, BIRC4, IAP3
Authors : Mastrangelo, E., Cossu, F., Bolognesi, M., Milani, M.
Keywords : zinc finger, APOPTOSIS INHIBITOR
Exp. method : X-RAY DIFFRACTION ( 3.30 Å )
Citation :

Structural insight into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic.

Cossu, F.,Milani, M.,Vachette, P.  et al.
(2012)  Plos One  7 : e49527 - e49527

PubMed: 23166698
DOI: 10.1371/journal.pone.0049527

Reaction

Chain : A, B, C, D, E, J, F, G, K, L
UniProt : P98170 (XIAP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. 2.3.2.27 PubMed:19473982, PubMed:20154138, PubMed:21931591, PubMed:22304967, PubMed:22607974, PubMed:30026309
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