Het-PDB Navi2 (PDB: 4EBW)

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Ligands
Code	Name		Style	Show	Link
0PF	1-ethyl-8-(4-ethylphenyl)-5-methyl-1,5-dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-dioxide				PoSSuM

Non-standard Residues
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Download interaction data: 4EBW

Code :

4EBW PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Structure of Focal Adhesion Kinase catalytic domain in complex with novel allosteric inhibitor

Release Data :

2012-07-25

Compound :

mol_id	molecule	chains	synonym
1	Focal adhesion kinase 1	A	FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein phosphatase 1 regulatory subunit 71, PPP1R71, Protein-tyrosine kinase 2, p125FAK, pp125FAK
	ec: 2.7.10.2 fragment: unp residues 411-686

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: PTK2, FAK, FAK1 expression_system_common: Fall armyworm

Authors :

Iwatani, M., Iwata, H., Okabe, A., Skene, R.J., Tomita, N., Hayashi, Y., Aramaki, Y., Hosfield, D.J., Hori, A., Baba, A., Miki, H.

Keywords :

Kinase Domain, Allosteric inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.65 Å )

Citation :

Discovery and characterization of novel allosteric FAK inhibitors.

Iwatani, M.,Iwata, H.,Okabe, A. et al.
(2013) Eur.J.Med.Chem. 61 : 49 - 60

Chain :

UniProt :

Q05397 (FAK1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:10655584, PubMed:11331870, PubMed:18339875
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PDB ID: 4EBW