Brand  (β version)

PDB ID: 4EAY

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
CS2 D-mannonic acid PoSSuM
MN Manganese (II) ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 4EAY   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structures of mannonate dehydratase from Escherichia coli strain K12 complexed with D-mannonate
Release Data : 2013-03-27
Compound :
mol_id molecule chains synonym
1 Mannonate dehydratase A,B,C,D D-mannonate hydrolase
ec: 4.2.1.8
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:83333) Escherichia coli  (taxid:562)
strain: K12
gene: uxuA, b4322, JW4285
Authors : Qiu, X., Zhu, Y., Yuan, Y., Zhang, Y., Liu, H., Gao, Y., Teng, M., Niu, L.
Keywords : TIM Barrel, dehydratase, D-mannonate Binding, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.35 Å )
Citation :

Structural insights into decreased enzymatic activity induced by an insert sequence in mannonate dehydratase from Gram negative bacterium.

Qiu, X.,Tao, Y.,Zhu, Y.  et al.
(2012)  J.Struct.Biol.  180 : 327 - 334

PubMed: 22796868
DOI: 10.1016/j.jsb.2012.06.013

Reaction

Chain : A, B, C, D
UniProt : P24215 (UXUA_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O 4.2.1.8 PubMed:3038546
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