Brand  (β version)

PDB ID: 4E5H

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
MN Manganese (II) ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4E5H   PDBj   RCSB PDB   PDBe
Header : VIRAL PROTEIN, TRANSCRIPTION
Title : Crystal structure of avian influenza virus PAn bound to compound 3
Release Data : 2012-08-08
Compound :
mol_id molecule chains synonym
1 Polymerase protein PA A,B,C,D polymerase acidic protein
fragment: SEE REMARK 999
Source :
mol_id organism_scientific expression_system
1 Influenza A virus  (taxid:284218) Escherichia coli  (taxid:469008)
strain: A/Viet Nam/1203/2004
gene: PA
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET52b
Authors : DuBois, R.M., Slavish, P.J., Webb, T.R., White, S.W.
Keywords : endonuclease domain, H5N1 subtype, VIRAL PROTEIN, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.158 Å )
Citation :

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease.

Dubois, R.M.,Slavish, P.J.,Baughman, B.M.  et al.
(2012)  Plos Pathog.  8 : e1002830 - e1002830

PubMed: 22876176
DOI: 10.1371/journal.ppat.1002830

Reaction

Chain : A, B, C, D
UniProt : Q5EP34 (PA_I04A1)
Reaction : -
Cofactor: Evidence: Note:
Mn(2+) ECO:0000255 | HAMAP-Rule:MF_04063
ECO:0000269 | PubMed:22876176
Binds 2 manganese ions per subunit.