Het-PDB Navi2 (PDB: 4E5D)

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Ligands
Code	Name		Style	Show	Link
0NJ	2-(2-fluorophenyl)-6-methoxy-1,3-benzothiazole				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4E5D

Code :

4E5D PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR

Title :

2.2A resolution structure of a firefly luciferase-benzothiazole inhibitor complex

Release Data :

2012-09-05

Compound :

mol_id	molecule	chains	synonym
1	Luciferin 4-monooxygenase	A	Luciferase
	ec: 1.13.12.7

Source :

mol_id	organism_scientific	organism_common
1	Photinus pyralis (taxid:7054)	North American firefly
	other_details: Lyophilized power from Sigma-Aldrich Catalog# L9506

Authors :

Lovell, S., Battaile, K.P., Throne, N., Shen, M., Auld, D.S., Inglese, J.

Keywords :

OXIDOREDUCTASE, MONOOXYGENASE, PHOTOPROTEIN, LUMINESCENCE, profiling, PubChem, luciferase, quantitative high-throughput screening, qHTS, firefly luciferase, reporter-gene assays, adenylate forming enzymes, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.2010 Å )

Citation :

Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter.

Thorne, N.,Shen, M.,Lea, W.A. et al.
(2012) Chem.Biol. 19 : 1060 - 1072

PubMed: 22921073
DOI: 10.1016/j.chembiol.2012.07.015

Chain :

UniProt :

P08659 (LUCI_PHOPY)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + firefly D-luciferin + O2 = AMP + CO2 + diphosphate + firefly oxyluciferin + hnu	1.13.12.7	UniProtKB:Q26304
	-	UniProtKB:Q26304

PDB ID: 4E5D

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Structure summary

Reaction