Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0MY N-[4-(3-amino-1h-indazol-5-yl)phenyl]-3-chlorobenzenesulfonamide
Code : 4E20
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor
Release Data : 2012-10-03
Compound :
mol_id molecule chains
1 Non-receptor tyrosine-protein kinase TYK2 A
ec: 2.7.10.2
fragment: Tyk-2 catalytic domain (UNP Residues 881-1170)
mutation: D1016A
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Spodoptera frugiperda  (taxid:7108)
gene: Tyk2
expression_system_common: Fall Armyworm
expression_system_vector_type: virus
expression_system_plasmid: pDEST20
Authors : Argiriadi, M.A., Talanian, R.V., Borhani, D.W.
Keywords : kinase catalytic domain, kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.

Argiriadi, M.A.,Goedken, E.R.,Banach, D.  et al.
(2012)  Bmc Struct.Biol.  12 : 22 - 22

PubMed: 22995073
DOI: 10.1186/1472-6807-12-22

Chain : A
UniProt : Q9R117 (TYK2_MOUSE)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.