Het-PDB Navi2 (PDB: 4E1Z)

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Ligands
Code	Name		Style	Show	Link
0MX	N-[5-(4-{[(3-chlorophenyl)sulfonyl]amino}phenyl)-1h-indazol-3-yl]furan-2-carboxamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4E1Z

Code :

4E1Z PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor

Release Data :

2012-10-03

Compound :

mol_id	molecule	chains
1	Non-receptor tyrosine-protein kinase TYK2	A
	ec: 2.7.10.2 fragment: Tyk-2 catalytic domain (UNP Residues 880-1170) mutation: D1016A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	Mouse	Spodoptera frugiperda (taxid:7108)
	gene: Tyk2

Authors :

Argiriadi, M.A., Talanian, R.V., Borhani, D.W.

Keywords :

kinase catalytic domain, kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.50 Å )

Citation :

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.

Argiriadi, M.A.,Goedken, E.R.,Banach, D. et al.
(2012) Bmc Struct.Biol. 12 : 22 - 22

Chain :

UniProt :

Q9R117 (TYK2_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	UniProtKB:P29597
	-	UniProtKB:P29597

PDB ID: 4E1Z