Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0N5 N-{4-[(7-hydroxy-6-methoxyquinazolin-4-yl)amino]phenyl}benzamide
PG4 Tetraethylene glycol
SO4 Sulfate ion
Code : 4E1K   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : GlmU in complex with a Quinazoline Compound
Release Data : 2013-05-29
Compound :
mol_id molecule chains synonym
1 Bifunctional protein GlmU A UDP-N-acetylglucosamine pyrophosphorylase, N-acetylglucosamine-1-phosphate uridyltransferase, Glucosamine-1-phosphate N-acetyltransferase
ec: 2.7.7.23, 2.3.1.157
Source :
mol_id organism_scientific expression_system
1 Haemophilus influenzae  (taxid:71421) Escherichia coli  (taxid:562)
strain: ATCC 51907 / DSM 11121 / KW20 / Rd
gene: glmU, HI_0642
Authors : Larsen, N.A., Doig, P.
Keywords : peptidoglycan synthesis, cell shape, metal-binding, cell wall biogenesis/degradation, multifunctional enzyme, acyltransferase, uridyltransferase, Nucleotidyl transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode.

Larsen, N.A.,Nash, T.J.,Morningstar, M.  et al.
(2012)  Biochem.J.  446 : 405 - 413

PubMed: 22721802
DOI: 10.1042/BJ20120596

Chain : A
UniProt : P43889 (GLMU_HAEIN)
Reaction : Acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-acetyl-alpha-D-glucosamine 1-phosphate.
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.