Brand  (β version)

PDB ID: 4E0U

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Ligands
Code Name Style Show Link
0MV (3s)-3-(1h-indol-3-ylmethyl)-3,4-dihydro-1h-1,4-benzodiazepine-2,5-dione PoSSuM
PIS Trihydrogen thiodiphosphate PoSSuM
IMD Imidazole PoSSuM
EDO 1,2-ethanediol PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4E0U   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of CdpNPT in complex with thiolodiphosphate and (S)-benzodiazependione
Release Data : 2012-05-30
Compound :
mol_id molecule chains
1 Cyclic dipeptide N-prenyltransferase A,B
Source :
mol_id organism_scientific expression_system
1 Aspergillus fumigatus  (taxid:746128) Escherichia coli  (taxid:562)
gene: cdpNPT
expression_system_strain: ROSETTA2
expression_system_vector_type: PLASMID
expression_system_plasmid: PET28a
Authors : Schuller, J.M., Zocher, G., Stehle, T.
Keywords : PT-fold, C(3)b-prenyltransferase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Structure and catalytic mechanism of a cyclic dipeptide prenyltransferase with broad substrate promiscuity.

Schuller, J.M.,Zocher, G.,Liebhold, M.  et al.
(2012)  J.Mol.Biol.  422 : 87 - 99

PubMed: 22683356
DOI: 10.1016/j.jmb.2012.05.033

Reaction

Chain : A, B
UniProt : D1D8L6 (CDNTP_ASPFM)
Reaction: EC: Evidence:
Physiological Direction:
dimethylallyl diphosphate + harmol = 6-(3-dimethylallyl)harmol + diphosphate - PubMed:35767141
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H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] = L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide] 3.4.11.17 PubMed:18635009
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(R)-benzodiazepinedione + dimethylallyl diphosphate = (2S,3R,11R)-aszonalenin + diphosphate - PubMed:19421461
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(S)-benzodiazepinedione + dimethylallyl diphosphate = (2S,3R,11S)-aszonalenin + diphosphate - PubMed:19421461
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