Brand  (β version)

color scheme of protein:


interaction residue:

chain: Hide other chain(s)

Code Name Link
JKM 1-[(2s,3as,4s,6r,6ar)-2-hydroxy-6-(hydroxymethyl)-2-oxidotetrahydrofuro[3,4-D][1,3,2]dioxaphosphol-4-yl]pyrimidine-2,4( 1h,3h)-dione
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
SO4 Sulfate ion
Modified Residues
Code Name Link
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
Code : 4DVL
Title : Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with 2'-3'-cyclo-UMP
Release Data : 2012-05-23
Compound :
mol_id molecule chains
1 E(rns) glycoprotein A,B
fragment: N-terminal fragment
Source :
mol_id organism_scientific organism_common expression_system
1 Bovine viral diarrhea virus  (taxid:268305) BVDV Drosophila melanogaster  (taxid:7227)
strain: CP7
gene: Erns
expression_system_vector_type: plasmid
expression_system_plasmid: pMT-BIP-based
Authors : Krey, T., Bontems, F., Vonrhein, C., Vaney, M.-C., Bricogne, G., Ruemenapf, T., Rey, F.A.
Keywords : virus glycoprotein, T2 Ribonuclease, VIRAL PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.7500 Å )
Citation :

Crystal Structure of the Pestivirus Envelope Glycoprotein E(rns) and Mechanistic Analysis of Its Ribonuclease Activity.

Krey, T.,Bontems, F.,Vonrhein, C.  et al.
(2012)  Structure  20 : 862 - 873

PubMed: 22579253
DOI: 10.1016/j.str.2012.03.018

Chain : A, B
UniProt : Q96662 (POLG_BVDVC)
Reaction : Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3- NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
NTP + H(2)O = NDP + phosphate.
ATP + H(2)O = ADP + phosphate.