Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CL Chloride ion
0LA (2s)-2-(6-chloro-9h-carbazol-2-yl)propanoic acid
OHO Cyclohexane aminocarboxylic acid
Code : 4DO3
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Structure of FAAH with a non-steroidal anti-inflammatory drug
Release Data : 2013-01-23
Compound :
mol_id molecule chains synonym
1 Fatty-acid amide hydrolase 1 A,B Anandamide amidohydrolase 1, Oleamide hydrolase 1
ec: 3.5.1.99
fragment: UNP residues 32-575
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
gene: Faah, Faah1
Authors : Garau, G.
Keywords : AMIDASE, HYDROLASE, ANANDAMIDE, NSAID, DRUG, COX, INHIBITOR, INFLAMMATION, PAIN, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

A Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide Hydrolase.

Bertolacci, L.,Romeo, E.,Veronesi, M.  et al.
(2013)  J.Am.Chem.Soc.  135 : 22 - 25

PubMed: 23240907
DOI: 10.1021/ja308733u

Chain : A, B
UniProt : P97612 (FAAH1_RAT)
Reaction : Anandamide + H(2)O = arachidonic acid + ethanolamine.
Oleamide + H(2)O = oleic acid + NH(3).