Het-PDB Navi2 (PDB: 4DL2)

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Ligands
Code	Name	Link
0KX	2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine	PoSSuM
GOL	Glycerol	PoSSuM
MG	Magnesium ion	PoSSuM

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Download interaction data: 4DL2

Code :

4DL2 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/DNA/INHIBITOR

Title :

Human DNA polymerase eta inserting dCMPNPP opposite CG template (GG0a)

Release Data :

2012-05-09

Compound :

mol_id	molecule	chains	synonym
1	DNA polymerase eta	A	RAD30 homolog A, Xeroderma pigmentosum variant type protein
	ec: 2.7.7.7 fragment: unp residues 1-432

mol_id	molecule	chains
2	DNA (5'-D(APCPGPGPCPTPCPAPCPAPCPT)-3')	T

mol_id	molecule	chains
3	DNA (5'-D(TPAPGPTPGPTPGPAP*G)-3')	P
	other_details: dCMPNPP

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: POLH, RAD30, RAD30A, XPV expression_system_strain: BL21(DE3) plysS expression_system_vector_type: plasmid expression_system_plasmid: pET28

mol_id	organism_scientific
2
	synthetic: yes other_details: oligonucleotide, chain T

mol_id	organism_scientific
3
	synthetic: yes other_details: oligonucleotide, chain P

Authors :

Zhao, Y., Biertumpfel, C., Gregory, M., Hua, Y., Hanaoka, F., Yang, W.

Keywords :

cisplatin, chemoresistence, translesion synthesis, human DNA polymerse eta, kinetics, molecular splint, inhibition, DNA distorsion, second TLS polymerase, nucleotidyl transfer reaction, PCNA, TRANSFERASE-DNA-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.15 Å )

Citation :

Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta

Zhao, Y.,Biertumpfel, C.,Gregory, M.T. et al.
(2012) Proc.Natl.Acad.Sci.USA 109 : 7269 - 7274

PubMed: 22529383
DOI: 10.1073/pnas.1202681109

PDB ID: 4DL2

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