Brand  (β version)

PDB ID: 4DL1

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
0KY 3-[(2r)-2-ethoxypropyl]-2-thioxo-1,2,3,9-tetrahydro-6h-purin-6-one PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
CA Calcium ion PoSSuM
Non-standard Residues
Code Name Show
CSO S-hydroxycysteine
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
FUC Alpha-L-fucopyranose
Modification
Code Name Show

Structure summary

Code : 4DL1   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of human Myeloperoxidase with covalent thioxanthine analog
Release Data : 2012-03-21
Compound :
mol_id molecule chains
1 Myeloperoxidase light chain A,B,E,F,I,J,M,N
ec: 1.11.2.2
mol_id molecule chains
2 Myeloperoxidase heavy chain C,D,G,H,K,L,O,P
ec: 1.11.2.2
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
other_details: blood
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
Authors : Vajdos, F., Varghese, A.
Keywords : oxidoreductase, Heme-dependent peroxidase
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Deconstruction of activity-dependent covalent modification of heme in human neutrophil myeloperoxidase by multistage mass spectrometry (MS(4)).

Geoghegan, K.F.,Varghese, A.H.,Feng, X.  et al.
(2012)  Biochemistry  51 : 2065 - 2077

PubMed: 22352991
DOI: 10.1021/bi201872j

Reaction

Chain : C, D, G, H, K, L, O, P
UniProt : P05164 (PERM_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
chloride + H(+) + H2O2 = H2O + hypochlorous acid 1.11.2.2 PubMed:9922160
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