Brand  (β version)

PDB ID: 4DKL

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Ligands
Code Name Style Show Link
1PE Pentaethylene glycol PoSSuM
BF0 Methyl 4-{[(5beta,6alpha)-17-(cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-yl]amino}-4-oxobutanoate PoSSuM
CL Chloride ion PoSSuM
CLR Cholesterol PoSSuM
MPG [(z)-octadec-9-enyl] (2r)-2,3-bis(oxidanyl)propanoate PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4DKL   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN/ANTAGONIST
Title : Crystal structure of the mu-opioid receptor bound to a morphinan antagonist
Release Data : 2012-03-21
Compound :
mol_id molecule chains synonym
1 Mu-type opioid receptor, lysozyme chimera A Mu-opioid receptor, M-OR-1, MOR-1, Endolysin, Lysis protein, Muramidase
ec: 3.2.1.17
fragment: SEE REMARK 999
mutation: D1020N, C1054T, C1097A
Source :
mol_id organism_scientific organism_common expression_system
1 Enterobacteria phage T4  (taxid:10665) Mouse, bacteriophage T4 Spodoptera frugiperda  (taxid:7108)
gene: Mor, Oprm, Oprm1, E
expression_system_common: Fall armyworm
expression_system_strain: Sf9
expression_system_vector_type: baculovirus
expression_system_plasmid: pFastBac
Authors : Manglik, A., Kruse, A.C., Kobilka, T.S., Thian, F.S., Mathiesen, J.M., Sunahara, R.K., Pardo, L., Weis, W.I., Kobilka, B.K., Granier, S.
Keywords : G-protein coupled receptor, 7 transmembrane receptor, SIGNALING PROTEIN-ANTAGONIST complex
Exp. method : X-RAY DIFFRACTION ( 2.800 Å )
Citation :

Crystal structure of the {mu}-opioid receptor bound to a morphinan antagonist.

Manglik, A.,Kruse, A.C.,Kobilka, T.S.  et al.
(2012)  Nature  485 : 321 - 326

PubMed: 22437502
DOI: 10.1038/nature10954

Reaction

Chain : A
UniProt : P42866 (OPRM_MOUSE)
Reaction : -
Chain : A
UniProt : P00720 (ENLYS_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 HAMAP-Rule:MF_04110, PubMed:4865643
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