Brand  (β version)

PDB ID: 4DK8

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Ligands
Code Name Style Show Link
0KT N-methyl-N-(4-{(1s)-2,2,2-trifluoro-1-hydroxy-1-[1-(2-methoxyethyl)-1h-pyrrol-2-yl]ethyl}phenyl)benzenesulfonamide PoSSuM
ACT Acetate ion PoSSuM
CA Calcium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4DK8   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION/Peptide/Agonist
Title : Crystal structure of LXR ligand binding domain in complex with partial agonist 5
Release Data : 2012-03-21
Compound :
mol_id molecule chains synonym
1 Oxysterols receptor LXR-beta A,C Liver X receptor beta, Nuclear receptor NER, Nuclear receptor subfamily 1 group H member 2, Ubiquitously-expressed nuclear receptor
fragment: UNP residues 218-460
mol_id molecule chains synonym
2 Nuclear receptor coactivator 1 B,D NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1
ec: 2.3.1.48
fragment: UNP residues 745-756
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: NR1H2, LXRB, NER, UNR
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Piper, D.E., Kopecky, D.J., Xu, H.
Keywords : ligand binding domain, nuclear hormone receptor, TRANSCRIPTION-Peptide-Agonist complex
Exp. method : X-RAY DIFFRACTION ( 2.75 Å )
Citation :

Discovery of a new binding mode for a series of liver X receptor agonists.

Kopecky, D.J.,Jiao, X.Y.,Fisher, B.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 2407 - 2410

PubMed: 22406115
DOI: 10.1016/j.bmcl.2012.02.028

Reaction

Chain : A, C
UniProt : P55055 (NR1H2_HUMAN)
Reaction : -
Chain : B, D
UniProt : Q15788 (NCOA1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+) 2.3.1.48 -
-