PDB ID: 4DJY
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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0KR | (2e,5r)-5-cyclopropyl-2-imino-3-methyl-5-{3-[5-(prop-1-yn-1-yl)pyridin-3-yl]phenyl}imidazolidin-4-one | PoSSuM | |||
TLA | L(+)-tartaric acid | PoSSuM |
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Download interaction data: 4DJY
Structure summary
Code : | 4DJY PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||
Title : | Structure of BACE Bound to (R)-5-cyclopropyl-2-imino-3-methyl-5-(3-(5-(prop-1-yn-1-yl)pyridin-3-yl)phenyl)imidazolidin-4-one | ||||||||||||
Release Data : | 2012-03-21 | ||||||||||||
Compound : |
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Authors : | Strickland, C., Cumming, J. | ||||||||||||
Keywords : | BACE1, Alzheimers, HYDROLASE-HYDROLASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.8600 Å ) | ||||||||||||
Citation : |
Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor.
Cumming, J.N.,Smith, E.M.,Wang, L.
et al.
PubMed: 22390835 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P56817 (BACE1_HUMAN) | ||||||||
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