Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0KJ [(2s)-5-oxopyrrolidin-2-yl]methyl [(2s,3r)-4-{(1,3-benzothiazol-6-ylsulfonyl)[(2s)-2-methylbutyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate
PO4 Phosphate ion
Code : 4DJR
Header : HYDROLASE/HYDROLASE inhibitor
Title : Crystal Structure of wild-type HIV-1 Protease in Complex with MKP97
Release Data : 2012-08-01
Compound :
mol_id molecule chains synonym
1 Pol polyprotein A,B HIV-1 Protease
fragment: unp residues 1-99
mutation: Q7K
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus 1  (taxid:11676) Escherichia coli  (taxid:562)
strain: SF2
gene: gag-pol, pol
expression_system_strain: TAP56
expression_system_vector_type: plasmid
expression_system_plasmid: pXC35
Authors : Schiffer, C.A., Nalam, M.N.L.
Keywords : HIV-1 protease, drug resistance, drug design, Protease inhibitors, AIDS, Aspartyl protease, HYDROLASE-HYDROLASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.5500 Å )
Citation :

Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.

Parai, M.K.,Huggins, D.J.,Cao, H.  et al.
(2012)  J.Med.Chem.  55 : 6328 - 6341

PubMed: 22708897
DOI: 10.1021/jm300238h

Chain : A, B
UniProt : Q90K99 (No found in current UniProtKB/SwissProt)
Reaction : -