Brand  (β version)

PDB ID: 4DJF

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Ligands
Code Name Style Show Link
C2F 5-methyl-5,6,7,8-tetrahydrofolic acid PoSSuM
CA Calcium ion PoSSuM
COB Co-methylcobalamin PoSSuM
SF4 Iron/sulfur cluster PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4DJF   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/VITAMIN-BINDING PROTEIN
Title : Crystal structure of folate-bound corrinoid iron-sulfur protein (CFeSP) in complex with its methyltransferase (MeTr), co-crystallized with folate and Ti(III) citrate reductant
Release Data : 2012-03-14
Compound :
mol_id molecule chains
1 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase A,B
mol_id molecule chains synonym
2 Corrinoid/iron-sulfur protein large subunit C,E C/Fe-SP
mol_id molecule chains synonym
3 Corrinoid/iron-sulfur protein small subunit D,F C/Fe-SP
Source :
mol_id organism_scientific expression_system
1 Moorella thermoacetica  (taxid:1525) Escherichia coli  (taxid:562)
gene: acsE
mol_id organism_scientific
2 Moorella thermoacetica  (taxid:1525)
mol_id organism_scientific
3 Moorella thermoacetica  (taxid:1525)
Authors : Kung, Y., Drennan, C.L.
Keywords : TIM barrel, Rossmann fold, B12-dependent methyltransferase, TRANSFERASE-VITAMIN-BINDING PROTEIN complex
Exp. method : X-RAY DIFFRACTION ( 3.03 Å )
Citation :

Visualizing molecular juggling within a B12-dependent methyltransferase complex.

Kung, Y.,Ando, N.,Doukov, T.I.  et al.
(2012)  Nature  484 : 265 - 269

PubMed: 22419154
DOI: 10.1038/nature10916

Reaction

Chain : A, B
UniProt : Q46389 (ACSE_MOOTH)
Reaction: EC: Evidence:
Physiological Direction:
methyl-Co(III)-[corrinoid Fe-S protein] + (6S)-5,6,7,8- tetrahydrofolate = Co(I)-[corrinoid Fe-S protein] + (6S)-5-methyl- 5,6,7,8-tetrahydrofolate + H(+) 2.1.1.258 PubMed:17172470, PubMed:22419154, PubMed:7928975
-
Cofactor: Evidence: Note:
Ca(2+) ECO:0000269 | PubMed:17172470
ECO:0000269 | PubMed:22419154
-
Chain : C, E
UniProt : Q07340 (ACSC_MOOTH)
Reaction : -
Cofactor: Evidence: Note:
[4Fe-4S] cluster ECO:0000269 | PubMed:22419154
ECO:0000269 | PubMed:2821001
Binds 1 [4Fe-4S] cluster.
Chain : D, F
UniProt : Q07341 (ACSD_MOOTH)
Reaction : -