Het-PDB Navi2 (PDB: 4DHT)

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Ligands
Code	Name	Link
0KG	{2-[2-(cyclohexylamino)-2-oxoethoxy]phenyl}phosphonic acid	PoSSuM
CL	Chloride ion	PoSSuM
GOL	Glycerol	PoSSuM
MG	Magnesium ion	PoSSuM

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Download interaction data: 4DHT

Code :

4DHT PDBj RCSB PDB PDBe

Header :

PROTEIN BINDING/INHIBITOR

Title :

Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening

Release Data :

2013-07-31

Compound :

mol_id	molecule	chains	synonym
1	14-3-3 PROTEIN SIGMA	A	Epithelial cell marker protein 1, Stratifin
	fragment: UNP resiudes 1-231

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: HME1, SFN expression_system_strain: ROSETTA DE3 expression_system_vector_type: PLASMID expression_system_plasmid: PPROEX HTB

Authors :

Thiel, P., Roeglin, L., Kohlbacher, O., Ottmann, C.

Keywords :

HELICAL PROTEIN, ADAPTER PROTEIN, PHOSPHOPROTEIN BINDING, PROTEIN BINDING-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.8000 Å )

Citation :

Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.

Thiel, P.,Roglin, L.,Meissner, N. et al.
(2013) Chem.Commun.(Camb.) 49 : 8468 - 8470

PDB ID: 4DHT