Brand  (β version)

PDB ID: 4DFW

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
Non-standard Residues
Code Name Show
0LF (4r)-4-(4-phenylbutoxy)-L-proline
TPO Phosphothreonine
Glycosylation
Code Name Emphasize
Modification
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ACE Acetyl group
NH2 Amino group

Structure summary

Code : 4DFW   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION/Antagonist
Title : Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides
Release Data : 2012-03-28
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase PLK1 A Polo-like kinase 1, PLK-1, Serine/threonine-protein kinase 13, STPK13
ec: 2.7.11.21
mol_id molecule chains
2 Peptide D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PLK, PLK1
mol_id organism_scientific
2
synthetic: yes
Authors : Liu, F., Park, J.-E., Qian, W.-J., Lim, D., Gr ber, M., Berg, T., Yaffe, M.B., Lee, K.S., Burke Jr., T.R.
Keywords : phospho binding domain, TRANSCRIPTION-Antagonist complex
Exp. method : X-RAY DIFFRACTION ( 1.55 Å )
Citation :

Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides

Liu, F.,Park, J.-E.,Qian, W.-J.  et al.
(2012)  Chem.Biol. 

PubMed: 22292814

Reaction

Chain : A
UniProt : P53350 (PLK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.21 PubMed:11202906, PubMed:12207013, PubMed:21880710, PubMed:22325354, PubMed:37440612, PubMed:37674080
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.21 PubMed:11202906, PubMed:12207013, PubMed:21880710, PubMed:37674080
-