Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0JJ 7-methoxy-N-{[6-(3-methyl-1,2-thiazol-5-yl)[1,2,4]triazolo[4,3-B]pyridazin-3-yl]methyl}-1,5-naphthyridin-4-amine
Code : 4DEG
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of C-Met in complex with triazolopyridazine inhibitor 2
Release Data : 2012-05-30
Compound :
mol_id molecule chains synonym
1 Hepatocyte growth factor receptor A HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
ec: 2.7.10.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: MET
expression_system_vector_type: baculovirus
Authors : Whittington, D.A., Bellon, S.F., Long, A.M.
Keywords : proto-oncogene, receptor tyrosine kinase, RTK, ATP-binding, hepatocyte growth factor/scatter factor, HGF/SF, phosphoprotein, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.

Bode, C.M.,Boezio, A.A.,Albrecht, B.K.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 4089 - 4093

PubMed: 22595176
DOI: 10.1016/j.bmcl.2012.04.072

Chain : A
UniProt : P08581 (MET_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.