Het-PDB Navi2 (PDB: 4DEG)

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Ligands
Code	Name		Style	Show	Link
0JJ	7-methoxy-N-{[6-(3-methyl-1,2-thiazol-5-yl)[1,2,4]triazolo[4,3-B]pyridazin-3-yl]methyl}-1,5-naphthyridin-4-amine				PoSSuM

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Download interaction data: 4DEG

Code :

4DEG PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal structure of C-Met in complex with triazolopyridazine inhibitor 2

Release Data :

2012-05-30

Compound :

mol_id	molecule	chains	synonym
1	Hepatocyte growth factor receptor	A	HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
	ec: 2.7.10.1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Trichoplusia ni (taxid:7111)
	gene: MET expression_system_vector_type: baculovirus

Authors :

Whittington, D.A., Bellon, S.F., Long, A.M.

Keywords :

proto-oncogene, receptor tyrosine kinase, RTK, ATP-binding, hepatocyte growth factor/scatter factor, HGF/SF, phosphoprotein, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.

Bode, C.M.,Boezio, A.A.,Albrecht, B.K. et al.
(2012) Bioorg.Med.Chem.Lett. 22 : 4089 - 4093

PubMed: 22595176
DOI: 10.1016/j.bmcl.2012.04.072

Chain :

UniProt :

P08581 (MET_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028
	-	PROSITE-ProRule:PRU10028

PDB ID: 4DEG

Hetero Atom Contents

Structure summary

Reaction