Brand  (β version)

PDB ID: 4DA4

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Ligands
Code Name Style Show Link
SAH S-adenosyl-L-homocysteine PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
5CM 5-methyl-2'-deoxy-cytidine-5'-monophosphate
C49 4-thio,5-fluoro,5-methyl-2'-deoxy-cytidine-5'-monophosphate
Glycosylation
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Modification
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Structure summary

Code : 4DA4   PDBj   RCSB PDB   PDBe
Header : Transferase/DNA
Title : Structure of mouse DNMT1 (731-1602) bound to hemimethylated CpG DNA
Release Data : 2012-02-22
Compound :
mol_id molecule chains synonym
1 DNA (cytosine-5)-methyltransferase 1 A,B Dnmt1, Met-1, DNA methyltransferase MmuI, DNA MTase MmuI, M.MmuI, MCMT
ec: 2.1.1.37
fragment: UNP residues 731-1602
mol_id molecule chains
2 DNA_UPPER_STRAND C,E
mol_id molecule chains
3 DNA_LOWER_STRAND D,F
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:469008)
gene: Dnmt1, Dnmt, Met1, Uim
expression_system_strain: BL21(DE3)RIL
mol_id organism_scientific
2
synthetic: yes
other_details: Chemically synthesized
mol_id organism_scientific
3
synthetic: yes
other_details: Chemically synthesized
Authors : Song, J., Patel, D.J.
Keywords : Maintenance DNA methylation, Covalent Complex, Transferase-DNA complex
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation.

Song, J.,Teplova, M.,Ishibe-Murakami, S.  et al.
(2012)  Science  335 : 709 - 712

PubMed: 22323818
DOI: 10.1126/science.1214453

Reaction

Chain : A, B
UniProt : P13864 (DNMT1_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5- methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+) 2.1.1.37 PROSITE-ProRule:PRU10018
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