Het-PDB Navi2 (PDB: 4D9M)

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Ligands
Code	Name		Style	Show	Link
0JO	2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid				PoSSuM

Non-standard Residues
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Download interaction data: 4D9M

Code :

4D9M PDBj RCSB PDB PDBe

Header :

LYASE

Title :

Crystal structure of Diaminopropionate ammonia lyase from Escherichia coli in complex with aminoacrylate-PLP azomethine reaction intermediate

Release Data :

2012-04-25

Compound :

mol_id	molecule	chains	synonym
1	Diaminopropionate ammonia-lyase	A,B	Diaminopropionatase, Alpha,beta-diaminopropionate ammonia-lyase
	ec: 4.3.1.15

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:83333)	Escherichia coli (taxid:562)
	strain: K12 gene: b2871, JW2839, ygeX expression_system_strain: BL21(DE3)pLysS expression_system_vector_type: PLASMID expression_system_plasmid: pRSET-C

Authors :

Bisht, S., Rajaram, V., Bharath, S.R., Murthy, M.R.N.

Keywords :

Fold type II PLP-dependent enzyme, Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily, Lyase

Exp. method :

X-RAY DIFFRACTION ( 2.50 Å )

Citation :

Crystal Structure of Escherichia coli Diaminopropionate Ammonia-lyase Reveals Mechanism of Enzyme Activation and Catalysis

Bisht, S.,Rajaram, V.,Bharath, S.R. et al.
(2012) J.Biol.Chem. 287 : 20369 - 20381

Chain :

A, B

UniProt :

P66899 (DPAL_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(S)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate	4.3.1.15	PubMed:12596860
	-	PubMed:12596860
(R)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate	4.3.1.15	PubMed:12596860
	-	PubMed:12596860

PDB ID: 4D9M