Het-PDB Navi2 (PDB: 4D8N)

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Ligands
Code	Name		Style	Show	Link
0HM	2-{[4-(aminomethyl)phenyl]carbamoyl}-1-[(1-benzyl-1h-imidazol-2-yl)methyl]-3-hydroxypyridinium				PoSSuM

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Download interaction data: 4D8N

Code :

4D8N PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Human Kallikrein 6 Inhibitors with a para-Amidobenzylanmine P1 Group Carry a High Binding Efficiency

Release Data :

2012-03-21

Compound :

mol_id	molecule	chains	synonym
1	Kallikrein-6	A	Neurosin, Protease M, SP59, Serine protease 18, Serine protease 9, Zyme
	ec: 3.4.21.- mutation: R74G, R76Q, N132Q

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: KLK6, PRSS18, PRSS9 expression_system_common: Fall Armyworm expression_system_strain: sf9 expression_system_vector_type: baculovirus expression_system_plasmid: pBAC-3

Authors :

Chen, X., Xia, T., Wang, R.

Keywords :

human kallikrein 6, hk6, serine protease, protein-ligand complex, Amidinothiophene, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.68 Å )

Citation :

Human kallikrein 6 inhibitors with a para-amidobenzylanmine P1 group identified through virtual screening.

Liang, G.,Chen, X.,Aldous, S. et al.
(2012) Bioorg.Med.Chem.Lett. 22 : 2450 - 2455

PDB ID: 4D8N