Brand  (β version)

PDB ID: 4D7O

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Ligands
Code Name Style Show Link
0GD 6-[4-({[2-(3-fluorophenyl)ethyl]amino}methyl)phenyl]-4-methylpyridin-2-amine PoSSuM
ACT Acetate ion PoSSuM
H4B 5,6,7,8-tetrahydrobiopterin PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4D7O   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(4-(((3-Fluorophenethyl)amino)methyl)phenyl)-4- methylpyridin-2-amine
Release Data : 2015-07-01
Compound :
mol_id molecule chains synonym
1 NITRIC OXIDE SYNTHASE, BRAIN A,B BNOS, CONSTITUTIVE NOS, NC-NOS, NOS TYPE I, NEURONAL NOS, N-NOS, NNOS, PEPTIDYL-CYSTEINE S-NITROSYLASE NOS1, NEURONAL NITRIC OXIDE SYNTHASE
ec: 1.14.13.39
fragment: HEME DOMAIN RESIDUES 297-718
Source :
mol_id organism_scientific organism_common expression_system
1 RATTUS NORVEGICUS  (taxid:10116) NORWAY RAT ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_vector: PCWORI
Authors : Li, H., Poulos, T.L.
Keywords : OXIDOREDUCTASE, NITRIC OXIDE SYNTHASE, INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.78 Å )
Citation :

Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus Aureus

Holden, J.K.,Kang, S.,Beasley, F.C.  et al.
(2015)  Chem.Biol.  22 : 785

PubMed: 26091171
DOI: 10.1016/J.CHEMBIOL.2015.05.013

Reaction

Chain : A, B
UniProt : P29476 (NOS1_RAT)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide 1.14.13.39 PubMed:15548660, PubMed:1712077
left-to-right PubMed:1712077