Het-PDB Navi2 (PDB: 4D5H)

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Ligands
Code	Name		Style	Show	Link
9RM	6-methyl-5-{[3-(trifluoromethyl)phenyl]amino}-1,2,4-triazin-3(4h)-one				PoSSuM
SO4	Sulfate ion				PoSSuM

Non-standard Residues
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Download interaction data: 4D5H

Code :

4D5H PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Focal Adhesion Kinase catalytic domain

Release Data :

2015-02-18

Compound :

mol_id	molecule	chains	synonym
1	FOCAL ADHESION KINASE 1	A,B	FADK 1, FOCAL ADHESION KINASE-RELATED NONKINASE, FRNK, P41/P43FRNK, PROTEIN-TYROSINE KINASE 2, P125FAK, PP125FAK
	ec: 2.7.10.2 fragment: KINASE DOMAIN, RESIDUES 411-686

Source :

mol_id	organism_scientific	organism_common	expression_system
1	GALLUS GALLUS (taxid:9031)	CHICKEN	TRICHOPLUSIA NI (taxid:7111)
	expression_system_common: CABBAGE LOOPER expression_system_cell_line: High Five expression_system_vector_type: BACULOVIRUS expression_system_plasmid: PACG2T

Authors :

Le Coq, J., Lin, A., Lietha, D.

Keywords :

TRANSFERASE, KINASE INHIBITOR, ATP-BINDING, INTEGRIN SIGNALING

Exp. method :

X-RAY DIFFRACTION ( 1.75 Å )

Citation :

Allosteric Regulation of Focal Adhesion Kinase by Pip2 and ATP.

Zhou, J.,Bronowska, A.,Le Coq, J. et al.
(2015) Biophys.J. 108 : 698

Chain :

A, B

UniProt :

Q00944 (FAK1_CHICK)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)	2.7.10.2	PROSITE-ProRule:PRU10028
	-	PROSITE-ProRule:PRU10028

PDB ID: 4D5H