Brand  (β version)

PDB ID: 4D5H

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9RM 6-methyl-5-{[3-(trifluoromethyl)phenyl]amino}-1,2,4-triazin-3(4h)-one PoSSuM
SO4 Sulfate ion PoSSuM

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Non-standard Residues
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Glycosylation
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Structure summary

Code : 4D5H   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Focal Adhesion Kinase catalytic domain
Release Data : 2015-02-18
Compound :
mol_id molecule chains synonym
1 FOCAL ADHESION KINASE 1 A,B FADK 1, FOCAL ADHESION KINASE-RELATED NONKINASE, FRNK, P41/P43FRNK, PROTEIN-TYROSINE KINASE 2, P125FAK, PP125FAK
ec: 2.7.10.2
fragment: KINASE DOMAIN, RESIDUES 411-686
Source :
mol_id organism_scientific organism_common expression_system
1 GALLUS GALLUS  (taxid:9031) CHICKEN TRICHOPLUSIA NI  (taxid:7111)
expression_system_common: CABBAGE LOOPER
expression_system_cell_line: High Five
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PACG2T
Authors : Le Coq, J., Lin, A., Lietha, D.
Keywords : TRANSFERASE, KINASE INHIBITOR, ATP-BINDING, INTEGRIN SIGNALING
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

Allosteric Regulation of Focal Adhesion Kinase by Pip2 and ATP.

Zhou, J.,Bronowska, A.,Le Coq, J.  et al.
(2015)  Biophys.J.  108 : 698

PubMed: 25650936
DOI: 10.1016/J.BPJ.2014.11.3454

Reaction

Chain : A, B
UniProt : Q00944 (FAK1_CHICK)
Reaction: EC: Evidence:
Physiological Direction:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.10.2 PROSITE-ProRule:PRU10028
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