Het-PDB Navi2 (PDB: 4D0M)

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Ligands
Code	Name	Link
093	N-(5-(4-chloro-3-(2-hydroxy-ethylsulfamoyl)- phenylthiazole-2-yl)-acetamide	PoSSuM
GSP	5'-guanosine-diphosphate-monothiophosphate	PoSSuM
MG	Magnesium ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4D0M

Code :

4D0M PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN

Title :

Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3

Release Data :

2014-05-28

Compound :

mol_id	molecule	chains	synonym
1	PHOSPHATIDYLINOSITOL 4-KINASE BETA	A,C,G,I,M,O,Q,S,W,Y,c,g	PI4K-BETA, PI4KBETA, PTDINS 4-KINASE BETA, NPIK, PI4K92, PHOSPHATIDYLINOSITOL 4-KINASE III BETA
	ec: 2.7.1.67 mutation: YES other_details: HDX-OPTIMIZED DELETION VARIANT

mol_id	molecule	chains	synonym
2	RAS-RELATED PROTEIN RAB-11A	B,D,H,J,N,P,R,T,X,Z,d,h	RAB-11, YL8, RAB11A
	ec: 3.6.5.2 mutation: YES

mol_id	molecule	chains	synonym
3	RAB11 FAMILY-INTERACTING PROTEIN 3	E,F,K,L,U,V,a,b,e,f,i,j	FIP3-RAB11, RAB11-FIP3, ARFOPHILIN-1, EF HANDS-CONTAINING R AB-INTERACTING PROTEIN, EFERIN, MU-MB-17.148, FIP3
	fragment: RAB-BINDING DOMAIN mutation: YES

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	SPODOPTERA FRUGIPERDA (taxid:7108)
	expression_system_strain: SF9 expression_system_vector_type: BACULOVIRUS expression_system_plasmid: PACEBAC1-HSPI4KIIIB/PJB143

mol_id	organism_scientific	organism_common	expression_system
2	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:469008)
	expression_system_strain: BL21(DE3) expression_system_variant: C41 expression_system_vector_type: PLASMID expression_system_plasmid: POPTG/PJB88

mol_id	organism_scientific	organism_common	expression_system
3	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:469008)
	expression_system_strain: BL21(DE3) expression_system_variant: C41 expression_system_vector_type: PLASMID expression_system_vector: POPTG expression_system_plasmid: PJB164-POPTG-HSFIP3 (713-756)

Authors :

Burke, J.E., Inglis, A.J., Perisic, O., Masson, G.R., McLaughlin, S.H., Rutaganira, F., Shokat, K.M., Williams, R.L.

Keywords :

PHOSPHOINOSITIDE, PHOSPHATIDYLINOSITOL 4-KINASE, LIPID KINASE, FAMILY OF RAB INTERACTING PROTEINS, FIP3, RAB-BINDING DOMAIN, RBD, RAB11, GTP, PIK93, GOLGI, RECYCLING ENDOSOME, SIGNALING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 6.00 Å )

Citation :

Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors.

Burke, J.E.,Inglis, A.J.,Perisic, O. et al.
(2014) Science 344 : 1035

PubMed: 24876499
DOI: 10.1126/SCIENCE.1253397

Chain :

A, C, G, I, M, O, Q, S, W, Y, c, g

UniProt :

Q9UBF8 (PI4KB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)	2.7.1.67	PubMed:11277933, PubMed:9405935
	left-to-right	PubMed:11277933

Chain :

B, D, H, J, N, P, R, T, X, Z, d, h

UniProt :

P62491 (RB11A_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
GTP + H2O = GDP + H(+) + phosphate	3.6.5.2	PubMed:15837192, PubMed:16905101, PubMed:17007872, PubMed:17030804
GTP + H2O = GDP + H(+) + phosphate	left-to-right

Chain :	E, F, K, L, U, V, a, b, e, f, i, j
UniProt :	O75154 (RFIP3_HUMAN)
Reaction :	-

PDB ID: 4D0M

Hetero Atom Contents

Structure summary

Reaction