Brand  (β version)

PDB ID: 4D0L

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Ligands
Code Name Style Show Link
093 N-(5-(4-chloro-3-(2-hydroxy-ethylsulfamoyl)- phenylthiazole-2-yl)-acetamide PoSSuM
GSP 5'-guanosine-diphosphate-monothiophosphate PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4D0L   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/HYDROLASE
Title : Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS
Release Data : 2014-05-28
Compound :
mol_id molecule chains synonym
1 PHOSPHATIDYLINOSITOL 4-KINASE BETA A,C,E PHOSPHATIDYLINOSITOL 4-KINASE IIIBETA, PI4K-BETA, PI4KBETA, PTDINS 4-KINASE BETA, NPIK, PI4K92
ec: 2.7.1.67
fragment: RESIDUES 121-407,508-784
mutation: YES
other_details: HDX-OPTIMISED DELETION VARIANT
mol_id molecule chains synonym
2 RAS-RELATED PROTEIN RAB-11A B,D,F RAB11A, RAB-11, YL8
ec: 3.6.5.2
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PACEBAC1-HSPI4KIIIBETA
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PJB88 HSRAB11A-Q70L IN POPTG
Authors : Burke, J.E., Inglis, A.J., Perisic, O., Masson, G.R., McLaughin, S.H., Rutaganira, F., Shokat, K.M., Williams, R.L.
Keywords : TRANSFERASE-HYDROLASE COMPLEX, TRANSFERASE, PHOSPHATIDYLINOSITOL 4-KINASE, PI4K, NUCLEOTIDE, GTP, RAB11, PIK93, SIGNALING, GTPASE, SIGNAL TRANSDUCTION, GOLGI, RECYCLING ENDOSOME, PI4P, PHOSPHOINOSITIDE, PTDINS4P, PI4KB
Exp. method : X-RAY DIFFRACTION ( 2.94 Å )
Citation :

Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors.

Burke, J.E.,Inglis, A.J.,Perisic, O.  et al.
(2014)  Science  344 : 1035

PubMed: 24876499
DOI: 10.1126/SCIENCE.1253397

Reaction

Chain : A, C, E
UniProt : Q9UBF8 (PI4KB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+) 2.7.1.67 PubMed:11277933, PubMed:9405935
left-to-right PubMed:11277933
Chain : B, D, F
UniProt : P62491 (RB11A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate 3.6.5.2 PubMed:15837192, PubMed:16905101, PubMed:17007872, PubMed:17030804
left-to-right