Brand  (β version)

PDB ID: 4CWX

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
H4B 5,6,7,8-tetrahydrobiopterin PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
HW0 6-{[(3r,4r)-4-{[5-(6-aminopyridin-2-yl)pentyl]oxy}pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
CAS S-(dimethylarsenic)cysteine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4CWX   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE COMPLEX1
Release Data : 2014-08-13
Compound :
mol_id molecule chains
1 Nitric oxide synthase A,B
ec: 1.14.13.39
fragment: HEME DOMAIN, RESIDUES 40-482
Source :
mol_id organism_scientific organism_common expression_system
1 Bos taurus  (taxid:9913) Cattle ESCHERICHIA COLI  (taxid:469008)
gene: NOS3
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_vector: PCWORI
Authors : Li, H., Poulos, T.L.
Keywords : OXIDOREDUCTASE, NITRIC OXIDE SYNTHASE, INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.

Li, H.,Jamal, J.,Delker, S.L.  et al.
(2014)  Biochemistry  53 : 5272

PubMed: 25089924
DOI: 10.1021/BI500561H

Reaction

Chain : A, B
UniProt : F1MY54 (F1MY54_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide 1.14.13.39 ARBA:ARBA00035595
left-to-right