PDB ID: 4CTC
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Code | Name | Style | Show | Link | |
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J99 | (10r)-7-amino-3-cyclopropyl-12-fluoro-1,10,16-trimethyl-16,17-dihydro-1h-8,4-(metheno)pyrazolo[4,3-H][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | PoSSuM |
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Download interaction data: 4CTC
Structure summary
Code : | 4CTC PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 7-amino-3-cyclopropyl-12-fluoro-1,10,16-trimethyl-16,17- dihydro-1H-8,4-(metheno)pyrazolo(4,3-H)(2,5,11) benzoxadiazacyclotetradecin-15(10H)-one | ||||||||||||
Release Data : | 2014-05-28 | ||||||||||||
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Authors : | McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E. | ||||||||||||
Keywords : | TRANSFERASE, INHIBITOR | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.03 Å ) | ||||||||||||
Citation : |
Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
Johnson, T.W.,Richardson, P.F.,Bailey, S.
et al.
PubMed: 24819116 |
Reaction
Chain : | A | ||||||||
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UniProt : | Q9UM73 (ALK_HUMAN) | ||||||||
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