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Ligands
Code Name Style Show Link
FDB 2-amino-5-methyl-3h-pyrrolo[2,3-D]pyrimidin-4(7h)-one
NAP Nadp nicotinamide-adenine-dinucleotide phosphate
Non-standard Residues
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CSX S-oxy cysteine
Glycosylation
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Code : 4CLR   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor
Release Data : 2015-01-21
Compound :
mol_id molecule chains
1 PTERIDINE REDUCTASE 1 A,D
ec: 1.5.1.33
mol_id molecule chains
2 PTERIDINE REDUCTASE 1 B,C
ec: 1.5.1.33
Source :
mol_id organism_scientific expression_system
1 TRYPANOSOMA BRUCEI BRUCEI  (taxid:5702) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_vector: PET15B
mol_id organism_scientific expression_system
2 TRYPANOSOMA BRUCEI BRUCEI  (taxid:5702) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_vector: PET15B
Authors : Barrack, K.L., Hunter, W.N.
Keywords : OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1.

Khalaf, A.I.,Huggan, J.K.,Suckling, C.J.  et al.
(2014)  J.Med.Chem.  57 : 6479

PubMed: 25007262
DOI: 10.1021/JM500483B

Chain : B, C
UniProt : O76290 (O76290_TRYBB)
Reaction : -