Het-PDB Navi2 (PDB: 4CLR)

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Ligands
Code	Name		Style	Show	Link
FDB	2-amino-5-methyl-3h-pyrrolo[2,3-D]pyrimidin-4(7h)-one				PoSSuM
NAP	Nadp nicotinamide-adenine-dinucleotide phosphate				PoSSuM

Non-standard Residues
Code	Name	Show
CSX	S-oxy cysteine

Glycosylation
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Download interaction data: 4CLR

Code :

4CLR PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor

Release Data :

2015-01-21

Compound :

mol_id	molecule	chains
1	PTERIDINE REDUCTASE 1	A,D
	ec: 1.5.1.33

mol_id	molecule	chains
2	PTERIDINE REDUCTASE 1	B,C
	ec: 1.5.1.33

Source :

mol_id	organism_scientific	expression_system
1	TRYPANOSOMA BRUCEI BRUCEI (taxid:5702)	ESCHERICHIA COLI (taxid:469008)
	expression_system_strain: BL21(DE3) expression_system_vector_type: PLASMID expression_system_vector: PET15B

mol_id	organism_scientific	expression_system
2	TRYPANOSOMA BRUCEI BRUCEI (taxid:5702)	ESCHERICHIA COLI (taxid:469008)
	expression_system_strain: BL21(DE3) expression_system_vector_type: PLASMID expression_system_vector: PET15B

Authors :

Barrack, K.L., Hunter, W.N.

Keywords :

OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE

Exp. method :

X-RAY DIFFRACTION ( 1.75 Å )

Citation :

Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1.

Khalaf, A.I.,Huggan, J.K.,Suckling, C.J. et al.
(2014) J.Med.Chem. 57 : 6479

PDB ID: 4CLR