Brand  (β version)

PDB ID: 4CGM

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CWZ N-[[3-[3-(6,7-dihydro-4h-[1,3]thiazolo[5,4-C]pyridin-5-ylmethyl)phenyl]phenyl]methyl]-2-pyridin-3-yl-ethanamine PoSSuM
MG Magnesium ion PoSSuM
MYA Tetradecanoyl-CoA PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4CGM   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Leishmania major N-myristoyltransferase in complex with a biphenyl- derivative inhibitor
Release Data : 2014-07-09
Compound :
mol_id molecule chains
1 GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE A
ec: 2.3.1.97
fragment: RESIDUES 11-421
Source :
mol_id organism_scientific expression_system
1 LEISHMANIA MAJOR  (taxid:5664) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_variant: ROSETTA2 PLYSS
expression_system_vector_type: PLASMID
expression_system_vector: PET15-DERIVATIVE
expression_system_plasmid: MAC040-B01
Authors : Brannigan, J.A., Roberts, S.M., Bell, A.S., Hutton, J.A., Smith, D.F., Tate, E.W., Leatherbarrow, R.J., Wilkinson, A.J.
Keywords : TRANSFERASE, MYRISTOYLATION
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Diverse Modes of Binding in Structures of Leishmania Major N-Myristoyltransferase with Selective Inhibitors

Brannigan, J.A.,Roberts, S.M.,Bell, A.S.  et al.
(2014)  Iucrj  1 : 250

PubMed: 25075346
DOI: 10.1107/S2052252514013001

Reaction

Chain : A
UniProt : Q4Q5S8 (Q4Q5S8_LEIMA)
Reaction: EC: Evidence:
Physiological Direction:
N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein] 2.3.1.97 RuleBase:RU000586
-