PDB ID: 4CFN
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Structure summary
Code : | 4CFN PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | CELL CYCLE | ||||||||||||||||||||||||
Title : | Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors. | ||||||||||||||||||||||||
Release Data : | 2013-12-18 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Carbain, B., Paterson, D.J., Anscombe, E., Campbell, A., Cano, C., Echalier, A., Endicott, J., Golding, B.T., Haggerty, K., Hardcastle, I.R., Jewsbury, P., Newell, D.R., Noble, M.E.M., Roche, C., Wang, L.Z., Griffin, R. | ||||||||||||||||||||||||
Keywords : | CELL CYCLE, CYCLIN DEPENDENT KINASES, STRUCTURE-BASED DRUG DESIGN, CONFORMATIONAL RESTRAINT, REVERSED BINDING MODE | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.20 Å ) | ||||||||||||||||||||||||
Citation : |
8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode.
Carbain, B.,Paterson, D.J.,Anscombe, E.
et al.
PubMed: 24304238 |
Reaction
Chain : | A, C | ||||||||||||
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UniProt : | P24941 (CDK2_HUMAN) | ||||||||||||
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Chain : | B, D |
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UniProt : | P20248 (CCNA2_HUMAN) |
Reaction : | - |