Brand  (β version)

PDB ID: 4CFF

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Ligands
Code Name Style Show Link
STU Staurosporine PoSSuM
C1V 3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7h-thieno[2,3-B]pyridine-5-carbonitrile PoSSuM
AMP Adenosine monophosphate PoSSuM
Non-standard Residues
Code Name Show
TPO Phosphothreonine
SEP Phosphoserine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4CFF   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of full length human AMPK in complex with a small molecule activator, a thienopyridone derivative (A-769662)
Release Data : 2013-12-25
Compound :
mol_id molecule chains synonym
1 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 A,C AMPK SUBUNIT ALPHA-2, ACETYL-COA CARBOXYLASE KINASE, ACACA KINASE, HYDROXYMETHYLGLUTARYL-COA REDUCTASE KINASE, HMGCR KINASE
ec: 2.7.11.1, 2.7.11.27, 2.7.11.31
other_details: A 172 THR AND C 172 THR ARE PHOSPHORYLATED.
mol_id molecule chains synonym
2 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 B,D AMPK SUBUNIT BETA-1, AMPKB
other_details: B 108 SER AND D 108 SER ARE PHOSPHORYLATED.
mol_id molecule chains synonym
3 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1 E,F AMPK GAMMA1, AMPK SUBUNIT GAMMA-1, AMPKG
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
mol_id organism_scientific organism_common expression_system
3 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
Authors : Xiao, B., Sanders, M.J., Carmena, D., Bright, N.J., Haire, L.F., Underwood, E., Patel, B.R., Heath, R.B., Walker, P.A., Hallen, S., Giordanetto, F., Martin, S.R., Carling, D., Gamblin, S.J.
Keywords : TRANSFERASE, NUCLEOTIDE-BINDING, STAUROSPORINE-BINDING, SERINE/THREONINE-PROTEIN KINASE, ACTIVATOR, CARBOHYDRATE BINDING MODULE (CBM)
Exp. method : X-RAY DIFFRACTION ( 3.924 Å )
Citation :

Structural Basis of Ampk Regulation by Small Molecule Activators.

Xiao, B.,Sanders, M.J.,Carmena, D.  et al.
(2013)  Nat.Commun.  4 : 3017

PubMed: 24352254
DOI: 10.1038/NCOMMS4017

Reaction

Chain : A, C
UniProt : P54646 (AAPK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:28552616, PubMed:32029622, PubMed:36732624, PubMed:37079666
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 UniProtKB:Q09137
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ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O- phospho-L-seryl-[acetyl-CoA carboxylase] - UniProtKB:Q09137
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ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3- methylglutaryl-coenzyme A reductase] 2.7.11.31 UniProtKB:Q09137
-
Chain : B, D
UniProt : Q9Y478 (AAKB1_HUMAN)
Reaction : -
Chain : E, F
UniProt : P54619 (AAKG1_HUMAN)
Reaction : -