Het-PDB Navi2 (PDB: 4CF6)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
CBD	Cibacron blue				PoSSuM
FAD	Flavin-adenine dinucleotide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 4CF6

Code :

4CF6 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal structure of the complex of the P187S variant of human NAD(P) H:quinone oxidoreductase with Cibacron blue at 2.7 A resolution

Release Data :

2014-08-27

Compound :

mol_id	molecule	chains	synonym
1	NAD(P)H DEHYDROGENASE [QUINONE] 1	A,B	AZOREDUCTASE, DT-DIAPHORASE, DTD, MENADIONE REDUCTASE, NAD(P)H\:QUINONE OXIDOREDUCTASE 1, PHYLLOQUINONE REDUCTASE, QUINONE REDUCTASE 1, QR1, NADPH QUINONE OXIDOREDUCTASE
	ec: 1.6.5.2 mutation: YES

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:511693)
	expression_system_strain: BL21 expression_system_variant: STAR expression_system_vector_type: PLASMID expression_system_vector: PET28A

Authors :

Lienhart, W.D., Gudipati, V., Uhl, M.K., Binter, A., Pulido, S., Saf, R., Zangger, K., Gruber, K., Macheroux, P.

Keywords :

FLAVOPROTEIN, OXIDOREDUCTASE, OXIDOREDUCTASE-INHIBITOR COMPLEX, SINGLE AMINO ACID EXCHANGE

Exp. method :

X-RAY DIFFRACTION ( 2.694 Å )

Citation :

Collapse of the Native Structure by a Single Amino Acid Exchange in Human Nad(P)H:Quinone Oxidoreductase (Nqo1).

Lienhart, W.D.,Gudipati, V.,Uhl, M.K. et al.
(2014) FEBS J. 281 : 4691

Chain :

A, B

UniProt :

P15559 (NQO1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a quinone + NADH + H(+) = a quinol + NAD(+)	1.6.5.2	PubMed:8999809, PubMed:9271353
a quinone + NADH + H(+) = a quinol + NAD(+)	left-to-right	PubMed:8999809, PubMed:9271353
a quinone + NADPH + H(+) = a quinol + NADP(+)	1.6.5.2	PubMed:9271353
a quinone + NADPH + H(+) = a quinol + NADP(+)	left-to-right	PubMed:9271353
ubiquinone-10 + NADH + H(+) = ubiquinol-10 + NAD(+)	-	PubMed:9271353
ubiquinone-10 + NADH + H(+) = ubiquinol-10 + NAD(+)	left-to-right	PubMed:9271353
menadione + NADH + H(+) = menadiol + NAD(+)	-	PubMed:8999809
menadione + NADH + H(+) = menadiol + NAD(+)	left-to-right	PubMed:8999809
Cofactor:	Evidence:	Note:
FAD	ECO:0000269 \| PubMed:28291250	-

PDB ID: 4CF6