Brand  (β version)

PDB ID: 4C7I

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Ligands
Code Name Style Show Link
DMS Dimethyl sulfoxide PoSSuM
JJ1 N-[(1s)-1-{[(1s)-5-amino-1-[(2-cyclohexylethyl)carbamoyl]pentyl]carbamoyl}-2-hydroxyethyl]-10-hydroxydecanamide PoSSuM
MG Magnesium ion PoSSuM
MYA Tetradecanoyl-CoA PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4C7I   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Leismania major N-myristoyltransferase in complex with a peptidomimetic (-OH) molecule
Release Data : 2014-09-24
Compound :
mol_id molecule chains
1 GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE A
ec: 2.3.1.97
fragment: RESIDUES 11-421
Source :
mol_id organism_scientific expression_system
1 LEISHMANIA MAJOR  (taxid:5664) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_variant: ROSETTA2 PLYSS
expression_system_vector_type: PLASMID
expression_system_vector: PET15-DERIVATIVE
expression_system_plasmid: MAC040-B01
Authors : Olaleye, T.O., Brannigan, J.A., Goncalves, V., Roberts, S.M., Leatherbarrow, R.J., Wilkinson, A.J., Tate, E.W.
Keywords : TRANSFERASE, MYRISTOYLATION
Exp. method : X-RAY DIFFRACTION ( 1.30 Å )
Citation :

Peptidomimetic Inhibitors of N-Myristoyltransferase from Human Malaria and Leishmaniasis Parasites.

Olaleye, T.O.,Brannigan, J.A.,Roberts, S.M.  et al.
(2014)  Org.Biomol.Chem.  12 : 8132

PubMed: 25230674
DOI: 10.1039/C4OB01669F

Reaction

Chain : A
UniProt : Q4Q5S8 (Q4Q5S8_LEIMA)
Reaction: EC: Evidence:
Physiological Direction:
N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein] 2.3.1.97 RuleBase:RU000586
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