Brand  (β version)

PDB ID: 4C7B

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Ligands
Code Name Style Show Link
BVB 5-[(E)-2-(4-bromophenyl)ethenyl]benzene-1,3-diol PoSSuM
GOL Glycerol PoSSuM
IPA Isopropyl alcohol PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
FDL N~6~-acetyl-N-(4-methyl-2-oxo-2h-chromen-7-yl)-L-lysinamide
Glycosylation
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Modification
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Structure summary

Code : 4C7B   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/PEPTIDE
Title : Complex of human Sirt3 with Bromo-Resveratrol and Fluor-De-Lys peptide
Release Data : 2013-11-20
Compound :
mol_id molecule chains
1 NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL A
ec: 3.5.1.-
fragment: RESIDUES 117-399
mol_id molecule chains
2 PEPTIDE B
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_variant: ROSETTA2
expression_system_vector_type: PLASMID
expression_system_plasmid: PVFT3S
mol_id organism_scientific
2 SYNTHETIC CONSTRUCT  (taxid:32630)
synthetic: yes
Authors : Nguyen, G.T.T., Gertz, M., Weyand, M., Steegborn, C.
Keywords : HYDROLASE-PEPTIDE COMPLEX, HYDROLASE, SIRTUIN, INHIBITOR, ACTIVATION, RESVERATROL, SIRT1, METABOLIC SENSOR, METABOLISM, AGING
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Crystal Structures of Sirt3 Complexes with 4'-Bromo-Resveratrol Reveal Binding Sites and Inhibition Mechanism.

Nguyen, G.T.T.,Gertz, M.,Steegborn, C.
(2013)  Chem.Biol.  20 : 1375

PubMed: 24211137
DOI: 10.1016/J.CHEMBIOL.2013.09.019

Reaction

Chain : A
UniProt : Q9NTG7 (SIR3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide 2.3.1.286 PROSITE-ProRule:PRU00236, PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:19535340, PubMed:24121500, PubMed:23283301
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