Het-PDB Navi2 (PDB: 4C57)

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Ligands
Code	Name	Link
SO4	Sulfate ion	PoSSuM
EDO	1,2-ethanediol	PoSSuM
FEF	(2z,3e)-2,3'-biindole-2',3(1h,1'H)-dione 3-{O-[(3r)-3,4-dihydroxybutyl]oxime}	PoSSuM

Non-standard Residues
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Download interaction data: 4C57

Code :

4C57 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Structure of GAK kinase in complex with a nanobody

Release Data :

2013-10-09

Compound :

mol_id	molecule	chains
1	Cyclin-G-associated kinase	A,B
	ec: 2.7.11.1 fragment: KINASE DOMAIN RESIDUES 14-351

mol_id	molecule	chains
2	NANOBODY	C,D

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	ESCHERICHIA COLI (taxid:469008)
	gene: GAK expression_system_strain: BL21(DE3) expression_system_variant: R3 expression_system_vector_type: PLASMID expression_system_plasmid: PNIC28-BSA4

mol_id	organism_scientific	organism_common	expression_system
2	LAMA GLAMA (taxid:9844)	LLAMA	Escherichia coli (taxid:562)

Authors :

Chaikuad, A., Keates, T., Krojer, T., Allerston, C.K., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S.

Keywords :

TRANSFERASE, KINASE, CONFORMATIONAL PLASTICITY, ACTIVATION

Exp. method :

X-RAY DIFFRACTION ( 2.55 Å )

Citation :

Structure of Cyclin G-Associated Kinase (Gak) Trapped in Different Conformations Using Nanobodies.

Chaikuad, A.,Keates, T.,Vincke, C. et al.
(2014) Biochem.J. 459 : 59

Chain :

A, B

UniProt :

O14976 (GAK_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.1	-
	-	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.1	-
	-	-

PDB ID: 4C57