Brand  (β version)

PDB ID: 4BW3

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
9BM 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-1,5-naphthyridine-3-carboxylic acid PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4BW3   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand
Release Data : 2013-09-11
Compound :
mol_id molecule chains synonym
1 BROMODOMAIN-CONTAINING PROTEIN 4 A BRD4, PROTEIN HUNK1
fragment: N-TERMINAL BROMODOMAIN, RESIDUES 44-168
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
Authors : Chung, C., Mirguet, O., Lamotte, Y., Bamborough, P., Delannee, D., Bouillot, A., Gellibert, F., Krysa, G., Lewis, A., Witherington, J., Huet, P., Dudit, Y., Trottet, L., Nicodeme, E.
Keywords : TRANSCRIPTION, INHIBITOR, HISTONE, EPIGENETIC READER, ANTAGONIST
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

Naphthyridines as Novel Bet Family Bromodomain Inhibitors.

Mirguet, O.,Lamotte, Y.,Chung, C.  et al.
(2014)  Chemmedchem  9 : 589

PubMed: 24000170
DOI: 10.1002/CMDC.201300259

Reaction

Chain : A
UniProt : O60885 (BRD4_HUMAN)
Reaction : -