Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CL Chloride ion
FPL 5-fluoro-2-phenoxyphenol
GLU Glutamic acid
NAP Nadp nicotinamide-adenine-dinucleotide phosphate
Code : 4BNK
Header : OXIDOREDUCTASE
Title : Crystal structure of S. aureus FabI in complex with NADP and 5-fluoro- 2-phenoxyphenol
Release Data : 2013-06-05
Compound :
mol_id molecule chains synonym
1 ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH] A,B,C,D,E,F,G,H ENOYL-ACP REDUCTASE, ENR
ec: 1.3.1.10
mutation: YES
Source :
mol_id organism_scientific expression_system
1 STAPHYLOCOCCUS AUREUS SUBSP. AUREUS  (taxid:158879) ESCHERICHIA COLI  (taxid:469008)
strain: N315
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PETM-11
Authors : Schiebel, J., Chang, A., Bommineni, G.R., Tonge, P.J., Kisker, C.
Keywords : OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE SUPERFAMILY, FATTY ACID BIOSYNTHESIS, LIPID SYNTHESIS, SAFABI
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex.

Chang, A.,Schiebel, J.,Yu, W.  et al.
(2013)  Biochemistry  52 : 4217

PubMed: 23697754
DOI: 10.1021/BI400413C

Chain : A, B, C, D, E, F, G, H
UniProt : Q7A6D8 (No found in current UniProtKB/SwissProt)
Reaction : -