Het-PDB Navi2 (PDB: 4BNK)

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Ligands
Code	Name	Link
NAP	Nadp nicotinamide-adenine-dinucleotide phosphate	PoSSuM
FPL	5-fluoro-2-phenoxyphenol	PoSSuM
GLU	Glutamic acid	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4BNK

Code :

4BNK PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal structure of S. aureus FabI in complex with NADP and 5-fluoro- 2-phenoxyphenol

Release Data :

2013-06-05

Compound :

mol_id	molecule	chains	synonym
1	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH]	A,B,C,D,E,F,G,H	ENOYL-ACP REDUCTASE, ENR
	ec: 1.3.1.10 mutation: YES

Source :

mol_id	organism_scientific	expression_system
1	STAPHYLOCOCCUS AUREUS SUBSP. AUREUS (taxid:158879)	ESCHERICHIA COLI (taxid:469008)
	strain: N315 expression_system_strain: BL21(DE3) expression_system_vector_type: PLASMID expression_system_plasmid: PETM-11

Authors :

Schiebel, J., Chang, A., Bommineni, G.R., Tonge, P.J., Kisker, C.

Keywords :

OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE SUPERFAMILY, FATTY ACID BIOSYNTHESIS, LIPID SYNTHESIS, SAFABI

Exp. method :

X-RAY DIFFRACTION ( 2.50 Å )

Citation :

Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex.

Chang, A.,Schiebel, J.,Yu, W. et al.
(2013) Biochemistry 52 : 4217

PDB ID: 4BNK