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Ligands
Code Name Style Show Link
FAR Farnesyl
PE4 2-{2-[2-(2-{2-[2-(2-ethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethanol
Non-standard Residues
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SEP Phosphoserine
Glycosylation
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Modification
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Code : 4BG6   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : 14-3-3 interaction with Rnd3 prenyl-phosphorylation motif
Release Data : 2013-05-29
Compound :
mol_id molecule chains synonym
1 14-3-3 PROTEIN ZETA/DELTA A,B PROTEIN KINASE C INHIBITOR PROTEIN 1, KCIP-1
mol_id molecule chains synonym
2 RHO-RELATED GTP-BINDING PROTEIN RHOE Q,R PROTEIN MEMB, RHO FAMILY GTPASE 3, RHO-RELATED GTP-BINDING PROTEIN RHO8, RND3
fragment: C-TERMINUS, RESIDUES 232-241
other_details: FARNESYLATION ON CYS 347
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_variant: STAR
mol_id organism_scientific organism_common
2 HOMO SAPIENS  (taxid:9606) HUMAN
synthetic: yes
Authors : Riou, P., Kjaer, S., Purkiss, A., O'Reilly, N., McDonald, N.Q.
Keywords : SIGNALING PROTEIN, PRENYLATION, ACTIN CYTOSKELETON
Exp. method : X-RAY DIFFRACTION ( 2.300 Å )
Citation :

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins.

Riou, P.,Kjaer, S.,Garg, R.  et al.
(2013)  Cell(Cambridge,Mass.)  153 : 640

PubMed: 23622247
DOI: 10.1016/J.CELL.2013.03.044

Chain : A, B
UniProt : P63104 (1433Z_HUMAN)
Reaction : -
Chain : Q, R
UniProt : P61587 (RND3_HUMAN)
Reaction : -