Brand  (β version)

color scheme of protein:

hetatm:
centroid:

chain:

Ligands
Code Name Link
CL Chloride ion
HO Holmium atom
Code : 4BDW
Header : HYDROLASE
Title : The structure of the FnI-EGF tandem domain of coagulation factor XII in complex with Holmium
Release Data : 2013-02-13
Compound :
mol_id molecule chains synonym
1 COAGULATION FACTOR XIIA HEAVY CHAIN A COAGULATION FACTOR XII, HAGEMAN FACTOR, HAF
ec: 3.4.21.38
fragment: FNI-EGF, RESIDUES 133-215
Source :
mol_id organism_scientific expression_system
1 HOMO SAPIENS  (taxid:9606) KOMAGATAELLA PASTORIS  (taxid:4922)
expression_system_strain: X-33
expression_system_vector_type: PLASMID
expression_system_plasmid: PPICZALPHA
Authors : Beringer, D.X., Kroon-Batenburg, L.M.J.
Keywords : HYDROLASE, FNI DOMAIN, EGF DOMAIN
Exp. method : X-RAY DIFFRACTION ( 2.501 Å )
Citation :

The Structure of the Fni-Egf-Like Tandem Domain of Coagulation Factor Xii Solved Using Siras.

Beringer, D.X.,Kroon-Batenburg, L.M.J.
(2013)  Acta Crystallogr.,Sect.F  69 : 94

PubMed: 23385745
DOI: 10.1107/S1744309113000286

Chain : A
UniProt : P00748 (FA12_HUMAN)
Reaction : Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.