Brand  (β version)

PDB ID: 4BDS

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
FPK 1-formyl-L-proline PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
THA Tacrine PoSSuM
UNX Unknown atom or ion PoSSuM
FUC Alpha-L-fucopyranose PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
FUL Beta-L-fucopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 4BDS   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Human butyrylcholinesterase in complex with tacrine
Release Data : 2013-05-29
Compound :
mol_id molecule chains synonym
1 CHOLINESTERASE A BUTYRYLCHOLINESTERASE, ACYLCHOLINE ACYLHYDROLASE, BUTYRYLCHOLINE ESTERASE, CHOLINE ESTERASE II, PSEUDOCHOLINESTERASE
ec: 3.1.1.8
fragment: CATALYTIC DOMAIN, RESIDUES 29-557
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN CRICETULUS GRISEUS  (taxid:10029)
expression_system_common: CHINESE HAMSTER
expression_system_cell_line: CHO-K1
expression_system_vector_type: PLASMID
expression_system_plasmid: PGS
Authors : Nachon, F., Carletti, E., Ronco, C., Trovaslet, M., Nicolet, Y., Jean, L., Renard, P.-Y.
Keywords : HYDROLASE, NERVE TRANSMISSION, INHIBITIOR, ALPHA-BETA HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.100 Å )
Citation :

Crystal Structures of Human Cholinesterases in Complex with Huprine W and Tacrine: Elements of Specificity for Anti-Alzheimer'S Drugs Targeting Acetyl- and Butyrylcholinesterase.

Nachon, F.,Carletti, E.,Ronco, C.  et al.
(2013)  Biochem.J.  453 : 393

PubMed: 23679855
DOI: 10.1042/BJ20130013

Reaction

Chain : A
UniProt : P06276 (CHLE_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an acylcholine + H2O = a carboxylate + choline + H(+) 3.1.1.8 PubMed:19368529, PubMed:19452557
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