Brand  (β version)

PDB ID: 4BCC

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
JKT Tert-butyl N-[[1-[(3s,5s)-5-[(2s)-2-[azanyl(oxidanyl)methyl]pyrrolidin-1-yl]carbonyl-1-(4-phenylbutanoyl)pyrrolidin-3-yl]-1,2,3-triazol-4-yl]methyl]carbamate PoSSuM
TAM Tris(hydroxyethyl)aminomethane PoSSuM
Non-standard Residues
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Structure summary

Code : 4BCC   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND P2- substituted N-acyl-prolylpyrrolidine inhibitor
Release Data : 2013-03-13
Compound :
mol_id molecule chains synonym
1 PROLYL ENDOPEPTIDASE A PE, POST-PROLINE CLEAVING ENZYME
ec: 3.4.21.26
Source :
mol_id organism_scientific organism_common expression_system
1 SUS SCROFA  (taxid:9823) PIG ESCHERICHIA COLI  (taxid:562)
organ: BRAIN
expression_system_strain: JM105
Authors : VanDerVeken, P., Fulop, V., Rea, D., Gerard, M., VanElzen, R., Joossens, J., Cheng, J.D., Baekelandt, V., DeMeester, I., Lambeir, A.M., Augustyns, K.
Keywords : ALPHA-BETA-HYDROLASE, AMNESIA, HYDROLASE, PARKINSONS DISEASE, ALZHEIMERS DISEASE, INHIBITOR
Exp. method : X-RAY DIFFRACTION ( 1.65 Å )
Citation :

P2-Substituted N-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy.

Van Der Veken, P.,Fulop, V.,Rea, D.  et al.
(2012)  J.Med.Chem.  55 : 9856

PubMed: 23121075
DOI: 10.1021/JM301060G

Reaction

Chain : A
UniProt : P23687 (PPCE_PIG)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides. 3.4.21.26 -
-