Brand  (β version)

PDB ID: 4B7T

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Ligands
Code Name Style Show Link
CWT (5z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-methyl-2-(propan-2-ylamino)imidazol-4-one PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4B7T   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/PEPTIDE
Title : Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Leucettine L4
Release Data : 2013-01-30
Compound :
mol_id molecule chains synonym
1 GLYCOGEN SYNTHASE KINASE-3 BETA A GSK-3 BETA, SERINE/THREONINE-PROTEIN KINASE GSK3B
ec: 2.7.11.26, 2.7.11.1
fragment: RESIDUES 35-384
mol_id molecule chains synonym
2 AXIN-1 B AXIS INHIBITION PROTEIN 1, HAXIN
fragment: RESIDUES 383-400
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
expression_system_vector: PFASTBAC HTA
mol_id organism_scientific organism_common
2 HOMO SAPIENS  (taxid:9606) HUMAN
synthetic: yes
Authors : Oberholzer, A.E., Pearl, L.H.
Keywords : TRANSFERASE-PEPTIDE COMPLEX, TRANSFERASE, INSULIN PATHWAY, WNT SIGNALING PATHWAY, INHIBITOR
Exp. method : X-RAY DIFFRACTION ( 2.772 Å )
Citation :

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.

Tahtouh, T.,Elkins, J.M.,Filippakopoulos, P.  et al.
(2012)  J.Med.Chem.  55 : 9312

PubMed: 22998443
DOI: 10.1021/JM301034U

Reaction

Chain : A
UniProt : P49841 (GSK3B_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+) 2.7.11.26 PubMed:14690523
-
L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H(+) 2.7.11.26 PubMed:14690523
-
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:17050006, PubMed:21343617, PubMed:22539723, PubMed:25827072, PubMed:28992046, PubMed:29059170
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:17050006
-
Chain : B
UniProt : O15169 (AXIN1_HUMAN)
Reaction : -