Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CWT (5z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-methyl-2-(propan-2-ylamino)imidazol-4-one
Code : 4B7T
Header : TRANSFERASE/PEPTIDE
Title : Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Leucettine L4
Release Data : 2013-01-30
Compound :
mol_id molecule chains synonym
1 GLYCOGEN SYNTHASE KINASE-3 BETA A GSK-3 BETA, SERINE/THREONINE-PROTEIN KINASE GSK3B
ec: 2.7.11.26, 2.7.11.1
fragment: RESIDUES 35-384
mol_id molecule chains synonym
2 AXIN-1 B AXIS INHIBITION PROTEIN 1, HAXIN
fragment: RESIDUES 383-400
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
expression_system_vector: PFASTBAC HTA
mol_id organism_scientific organism_common
2 HOMO SAPIENS  (taxid:9606) HUMAN
synthetic: yes
Authors : Oberholzer, A.E., Pearl, L.H.
Keywords : TRANSFERASE-PEPTIDE COMPLEX, TRANSFERASE, INSULIN PATHWAY, WNT SIGNALING PATHWAY, INHIBITOR
Exp. method : X-RAY DIFFRACTION ( 2.772 Å )
Citation :

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.

Tahtouh, T.,Elkins, J.M.,Filippakopoulos, P.  et al.
(2012)  J.Med.Chem.  55 : 9312

PubMed: 22998443
DOI: 10.1021/JM301034U

Chain : A
UniProt : P49841 (GSK3B_HUMAN)
Reaction : ATP + [tau protein] = ADP + [tau protein] phosphate.
ATP + a protein = ADP + a phosphoprotein.
Chain : B
UniProt : O15169 (AXIN1_HUMAN)
Reaction : -