Brand  (β version)

PDB ID: 4B7P

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Ligands
Code Name Style Show Link
9UN 5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(1-methylpiperidin-4-yl)-1,2-oxazole-3-carboxamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4B7P   PDBj   RCSB PDB   PDBe
Header : CHAPERONE
Title : Structure of HSP90 with NMS-E973 inhibitor bound
Release Data : 2013-05-29
Compound :
mol_id molecule chains synonym
1 HEAT SHOCK PROTEIN HSP 90-ALPHA A HEAT SHOCK 86 KDA, HSP 86, HSP86, RENAL CARCINOMA ANTIGEN NY-REN-38
fragment: N-TERMINAL DOMAIN, RESIDUES 9-236
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:511693)
expression_system_strain: BL21
expression_system_vector_type: PLASMID
expression_system_vector: PET15
Authors : Fogliatto, G., Gianellini, L., Brasca, M.G., Casale, E., Ballinari, D., Ciomei, M., Degrassi, A., De Ponti, A., Germani, M., Guanci, M., Paolucci, M., Polucci, P., Russo, M., Sola, F., Valsasina, B., Visco, C., Zuccotto, F., Donati, D., Felder, E., Galvani, A., Pesenti, E., Mantegani, S., Isacchi, A.
Keywords : ATPASE, CHAPERONE, ATP-BINDING
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Nms-E973, a Novel Synthetic Inhibitor of Hsp90 with Activity in Models of Drug Resistance to Targeted Agents, Including Intracranial Metastases.

Fogliatto, G.,Gianellini, L.M.,Brasca, M.G.  et al.
(2013)  Clin.Cancer Res.  19 : 3520

PubMed: 23674492
DOI: 10.1158/1078-0432.CCR-12-3512

Reaction

Chain : A
UniProt : P07900 (HS90A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O = ADP + H(+) + phosphate 3.6.4.10 PubMed:12526792
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